I keep loosing spark from one side of coil so car fires on two cylinders, have replaced coil with four differant ones so i can rule that out, changed plugs, leads and re-wired all the loom from ecu. Thinking now it could be the coil drivers.
All ideas welcome.

Sounds plausible

worth swapping the connectors (and HT leads) to see if the problem swaps sides ?

could equally be the wiring or bad connection/solderjoint as the coil driver

Are the coil drivers getting hot?

I went with EDIS on my install due to being a tad wary of the potential of a coil driver stopping me from getting home - esp as it relies on setting things up correctly for 100% reliability- whereas the EDIS is seemingly indestructible

I believe the newer coil drivers tend to "cut out" as a safety feature rather than just go pop and never work again
Worth checking dwell settings and the other voodoo that the coil driver setup requires

Regards
Rob

if they are not already swap them out for bip373's they are much more reliable

http://www.diyautotune.com/catalog/bosch-bip373-coil-driver-mod-kit-p-230.html